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Prokaryotic Genetics and Gene Expression
Chapter from the Massachusetts Institute of Technology (USA) introductory hypertextbook on molecular biology.
http://web.mit.edu/esgbio/www/pge/pgedir.h...
Intron
Wikipedia article on sections of genes that are eliminated by splicing in the formation of mature mRNA and therefore not expressed as proteins.
http://en.wikipedia.org/wiki/Intron
Transcription
Wikipedia article: in genetics the process by which a DNA sequence is converted to a corresponding RNA sequence.
http://en.wikipedia.org/wiki/Transcription...
Gene Regulatory Network
Wikipedia article on the mathematical modelling of gene expression as a network.
http://en.wikipedia.org/wiki/Gene_regulato...
Shine-Dalgarno sequence
Wikipedia article: signals the initiation of protein synthesis in bacteria.
http://en.wikipedia.org/wiki/Shine-Dalgarn...
RNA Zone
Extensive catalog of links in genomics and proteomics.
http://www.rnazone.com/
Role of the Ribosome
Illustrated explanation of the ribosomal protein synthesis by Gwen V. Childs, University of Texas, Galveston, TX.
http://cellbio.utmb.edu/cellbio/ribosome.h...
Messenger RNA
Wikipedia article on the RNA that carries information from DNA to protein synthesis.
http://en.wikipedia.org/wiki/Messenger_RNA
Serial Analysis of Gene Expression
Explanation of Serial Analysis of Gene Expression (SAGE), a method for analysis of gene expression patterns.
http://www.sagenet.org/
Anatomy of a Comparative Gene Expression Study
Clear explanation of the process of comparing the gene expression in two cell populations or tissue samples by fluorescent microarray technique.
http://www.cs.wustl.edu/~jbuhler/research/...
Transcription Factor
Proteins that specifically bind to promotor or enhancer regions on DNA and thereby control the transcription of the downstream gene.
http://en.wikipedia.org/wiki/Transcription...
Posttranslational modification
Wikipedia article: chemical modification of polypeptide chains after synthesis.
http://en.wikipedia.org/wiki/Posttranslati...
Exon
Wikipedia article on regions in genes that are expressed in mature mRNA and in proteins.
http://en.wikipedia.org/wiki/Exon
Epigenetic Station
With information, protocols and resources about epigenetics and DNA methylation and much advertising.
http://www.epigeneticstation.com
Expressed Sequence Tag
Wikipedia article: EST are short sub-sequences of genes, used in mRNA sequencing and in construction of DNA microarrays.
http://en.wikipedia.org/wiki/Expressed_seq...
Noncoding DNA
Wikipedia article: sections of DNA that do not contain codes for polypeptide sequences.
http://en.wikipedia.org/wiki/Noncoding_DNA
Imprinting
Wikipedia article on the suppressing of genes by chemical modification, depending on which parent they were received from.
http://en.wikipedia.org/wiki/Imprinting_%2...
European Sequencing of Tobacco
A collaboration between Advanced Technologies (Cambridge) Ltd and Tobacco Institute of Bergerac to sequence a large number of tobacco genes.
http://www.estobacco.info
Genomes to Life
The US Department of Energy at Oak Ridge program for research in moleular biology: goals and results.
http://doegenomestolife.org/
Operon
Wikipedia article: group of genes in primitive organisms that are controlled by one operator and one promoter to be activated together.
http://en.wikipedia.org/wiki/Operon
Eukaryotic Gene Expression Problem Set
Multiple choice questions about post-transcriptional modification of RNA, promoters, and nuclear RNA processing. From: University of Arizona, USA 1997.
http://www.biology.arizona.edu/molecular_b...
Protein biosynthesis
Wikipedia article: summary of the process by which the cell converts the DNA sequence proteins.
http://en.wikipedia.org/wiki/Protein_biosy...
Control of Gene Expression
A collection of diagrams illustrating the fundamentals of molecular biology.
http://www.accessexcellence.org/RC/VL/GG/c...
The Epigenome Network of Excellence
Network of research groups on heritable changes in gene expression without a change in DNA sequence, funded by the European Union.
http://www.epigenome-noe.net/
Pre-mRNA
Wikipedia article: RNA string syntesized in the cell nucleus before modification (splicing, polyadenylation) and export to the cytoplasm.
http://en.wikipedia.org/wiki/Pre-mRNA
Epigenetics
Article on the site of CellCentric on epigenetics.
http://www.cellcentric.co.uk/epigenetics.h...
Promoter
Wikipedia article: in genetics a sequence located upstream of a gene that enables its translation.
http://en.wikipedia.org/wiki/Promoter
SECIS element
Wikipedia article: Sequence that directs translation of UGA as selenocysteine insteado of using it as a stop codon.
http://en.wikipedia.org/wiki/SECIS_element
Translation
Wikipedia article: in genetics, the process by which ribosomes in the cytoplasm transfer the genetic code from a m-RNA sequence to an amino acid sequence in a polypeptide chain.
http://en.wikipedia.org/wiki/Translation_%...
Monocistronic
Wikipedia article: Messenger RNA that codes for one polypeptide string only.
http://en.wikipedia.org/wiki/Monocistronic
Enhancer
Wikipedia article on enhancers, short pieces of DNA which bind to trans-acting factors to enhance transcription levels of genes.
http://en.wikipedia.org/wiki/Enhancer
3'UTR
Wikipedia article on the untranslated regions at the ends of mRNA.
http://en.wikipedia.org/wiki/3%27_UTR
Induction of Repair Genes in Yeast
Mercier G., Denis Y., Marc P., Picard L. and Dutreix M.: Transcriptional induction of repair genes during slowing of replication in irradiated Saccharomyces cerevisiae. Mutation Research 487 (dec 2001)157-172: article and supporting background data.
http://www.curie.u-psud.fr/Equipe_Dutreix/...
Epigenetic inheritance
Transmission of information from a cell or multicellular organism to its descendants without that information being encoded in the nucleotide sequence of the gene. Wikipedia article.
http://en.wikipedia.org/wiki/Epigenetic_in...
Mammary Genome Anatomy Project
Forum to integrate various aspects of mammary gland biology, including cellular and developmental aspects, and to promote collaborations and the exchange of ideas, knowledge and resources at NIH, Maryland.
http://mammary.nih.gov/
Gene Expression
UCLA Molecular Biology Tutorials on gene expression and gene cloning
http://www.lsic.ucla.edu/ls3/tutorials
Alternative Splicing
Resource for intervention in the key steps in post-translocation regulatory process, with analysis tools and implications in pathologies. Maintained by Exonhit Therapeutics SA, Paris, France.
http://www.exonhit.com/alternativesplicing...
RiboWeb Project
Knowledge base that combines data on the structure of the prokaryotic 30S ribosomal subunit that initiates the translation of mRNA into protein, its function and related links and references.
http://smi-web.stanford.edu/projects/helix...
Genome-Wide Expression
Report on a project to analyze the transcriptional regulatory circuitry of the yeast cell. From the Young Lab at the Whitehead Institute for Biomedical Research.
http://web.wi.mit.edu/young/expression/hom...
Biochemistry of Nucleic Acids
Lecture notes on nucleic acid structure, DNA replication and repair, the genetic code and translation, as well as cancer genes, from Oregon State University, USA 2003.
http://oregonstate.edu/instruction/bb492/g...
Alternative Splicing
Wikipedia article on the process in eukaryotes in which the splicing process of a pre-mRNA can lead to different ripe mRNA molecules and therefore to different proteins.
http://en.wikipedia.org/wiki/Alternative_s...
Gene Expression: Transcription
Resource for transcription events during gene formation including schematic diagrams.
http://users.rcn.com/jkimball.ma.ultranet/...
Splicing
Wikipedia article: in genetics, the process of removing introns from mRNA in the cell nucleus before export to the cytoplasm and use as master for protein synthesis.
http://en.wikipedia.org/wiki/Splicing_%28g...
Spliceosome
Wikipedia article: particle composed of DNA and peptide chains that effects mRNA splicing in the cell nucleus of eucaryotic cells.
http://en.wikipedia.org/wiki/Spliceosome
Genetic Code
Wikipedia article on the relationship between the nucleic acid base sequence and the corresponding polypeptide amino acid sequence.
http://en.wikipedia.org/wiki/Genetic_code
Ribosomes
Explanation of how the information encoded in mRNA is translated into a polypeptide. Includes differences between prokaryotes and eukaryotes by John W. Kimball, now retired from Harvard College.
http://users.rcn.com/jkimball.ma.ultranet/...
Epigenetics
Wikipedia article on processes that lead to inheritance that is not reflected in the sequences of the nuclear DNA.
http://en.wikipedia.org/wiki/Epigenetics
Signal peptide
Wikipedia article: short peptide sequences that direct the post-translational transport of proteins after synthesis.
http://en.wikipedia.org/wiki/Signal_peptid...
Gene Expression
Independent forum for discussion of gene expression.
http://www.gnxp.com
Transfer RNA
Wikipedia article: small RNA molecules that transport amino acids to their positions on the ribosome during polypeptide synthesis.
http://en.wikipedia.org/wiki/Transfer_RNA
Gene Regulation
Wikipedia article on the mechanisms that regulate gene expression.
http://en.wikipedia.org/wiki/Gene_regulati...
Regulation of Gene Expression
Overview of different aspects of gene expression, including transcription, chromatin modification, and analysis of whole genomes, from Massachusetts Institute of Technology, Cambridge, Mass, USA.
http://web.wi.mit.edu/young/pub/regulation...
Gene Expression
Article in Wikipedia.
http://en.wikipedia.org/wiki/Gene_expressi...
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2006